随着计算病理学的发展，通过整个幻灯片图像（WSIS）的Gleason评分的深度学习方法具有良好的前景。由于WSIS的大小非常大，因此图像标签通常仅包含幻灯片级标签或有限的像素级标签。当前的主流方法采用了多个实体学习来预测格里森等级。但是，某些方法仅考虑幻灯片级标签，忽略了包含丰富本地信息的有限像素级标签。此外，考虑到像素级标签的另外方法忽略了像素级标签的不准确性。为了解决这些问题，我们根据多个实例学习框架提出了一个混合监督变压器。该模型同时使用幻灯片级标签和实例级别标签，以在幻灯片级别实现更准确的Gleason分级。通过在混合监督培训过程中引入有效的随机掩盖策略，进一步降低了实例级标签的影响。我们在SICAPV2数据集上实现了最新性能，视觉分析显示了实例级别的准确预测结果。源代码可从https://github.com/bianhao123/mixed_supervision获得。

多实例学习（MIL）是一种强大的工具，可以解决基于整个滑动图像（WSI）的病理学诊断中的弱监督分类。然而，目前的MIL方法通常基于独立和相同的分布假设，从而忽略不同实例之间的相关性。为了解决这个问题，我们提出了一个被称为相关的MIL的新框架，并提供了融合证明。基于此框架，我们设计了一种基于变压器的MIL（TMARMIL），其探讨了形态和空间信息。所提出的传输可以有效地处理不平衡/平衡和二元/多重分类，具有良好的可视化和可解释性。我们对三种不同的计算病理问题进行了各种实验，与最先进的方法相比，实现了更好的性能和更快的会聚。在CAMELYON16数据集中的二进制肿瘤分类的测试AUC最高可达93.09％。在TCGA-NSCLC数据集和TCGA-RCC数据集中，癌症亚型分类的AUC分别可以高达96.03％和98.82％。实现可用于：https://github.com/szc19990412/transmil。

Weakly-supervised object localization aims to indicate the category as well as the scope of an object in an image given only the image-level labels. Most of the existing works are based on Class Activation Mapping (CAM) and endeavor to enlarge the discriminative area inside the activation map to perceive the whole object, yet ignore the co-occurrence confounder of the object and context (e.g., fish and water), which makes the model inspection hard to distinguish object boundaries. Besides, the use of CAM also brings a dilemma problem that the classification and localization always suffer from a performance gap and can not reach their highest accuracy simultaneously. In this paper, we propose a casual knowledge distillation method, dubbed KD-CI-CAM, to address these two under-explored issues in one go. More specifically, we tackle the co-occurrence context confounder problem via causal intervention (CI), which explores the causalities among image features, contexts, and categories to eliminate the biased object-context entanglement in the class activation maps. Based on the de-biased object feature, we additionally propose a multi-teacher causal distillation framework to balance the absorption of classification knowledge and localization knowledge during model training. Extensive experiments on several benchmarks demonstrate the effectiveness of KD-CI-CAM in learning clear object boundaries from confounding contexts and addressing the dilemma problem between classification and localization performance.

Inferring missing links or detecting spurious ones based on observed graphs, known as link prediction, is a long-standing challenge in graph data analysis. With the recent advances in deep learning, graph neural networks have been used for link prediction and have achieved state-of-the-art performance. Nevertheless, existing methods developed for this purpose are typically discriminative, computing features of local subgraphs around two neighboring nodes and predicting potential links between them from the perspective of subgraph classification. In this formalism, the selection of enclosing subgraphs and heuristic structural features for subgraph classification significantly affects the performance of the methods. To overcome this limitation, this paper proposes a novel and radically different link prediction algorithm based on the network reconstruction theory, called GraphLP. Instead of sampling positive and negative links and heuristically computing the features of their enclosing subgraphs, GraphLP utilizes the feature learning ability of deep-learning models to automatically extract the structural patterns of graphs for link prediction under the assumption that real-world graphs are not locally isolated. Moreover, GraphLP explores high-order connectivity patterns to utilize the hierarchical organizational structures of graphs for link prediction. Our experimental results on all common benchmark datasets from different applications demonstrate that the proposed method consistently outperforms other state-of-the-art methods. Unlike the discriminative neural network models used for link prediction, GraphLP is generative, which provides a new paradigm for neural-network-based link prediction.

Human Activity Recognition (HAR) is one of the core research areas in mobile and wearable computing. With the application of deep learning (DL) techniques such as CNN, recognizing periodic or static activities (e.g, walking, lying, cycling, etc.) has become a well studied problem. What remains a major challenge though is the sporadic activity recognition (SAR) problem, where activities of interest tend to be non periodic, and occur less frequently when compared with the often large amount of irrelevant background activities. Recent works suggested that sequential DL models (such as LSTMs) have great potential for modeling nonperiodic behaviours, and in this paper we studied some LSTM training strategies for SAR. Specifically, we proposed two simple yet effective LSTM variants, namely delay model and inverse model, for two SAR scenarios (with and without time critical requirement). For time critical SAR, the delay model can effectively exploit predefined delay intervals (within tolerance) in form of contextual information for improved performance. For regular SAR task, the second proposed, inverse model can learn patterns from the time series in an inverse manner, which can be complementary to the forward model (i.e.,LSTM), and combining both can boost the performance. These two LSTM variants are very practical, and they can be deemed as training strategies without alteration of the LSTM fundamentals. We also studied some additional LSTM training strategies, which can further improve the accuracy. We evaluated our models on two SAR and one non-SAR datasets, and the promising results demonstrated the effectiveness of our approaches in HAR applications.

Occupancy information is useful for efficient energy management in the building sector. The massive high-resolution electrical power consumption data collected by smart meters in the advanced metering infrastructure (AMI) network make it possible to infer buildings' occupancy status in a non-intrusive way. In this paper, we propose a deep leaning model called ABODE-Net which employs a novel Parallel Attention (PA) block for building occupancy detection using smart meter data. The PA block combines the temporal, variable, and channel attention modules in a parallel way to signify important features for occupancy detection. We adopt two smart meter datasets widely used for building occupancy detection in our performance evaluation. A set of state-of-the-art shallow machine learning and deep learning models are included for performance comparison. The results show that ABODE-Net significantly outperforms other models in all experimental cases, which proves its validity as a solution for non-intrusive building occupancy detection.

Despite recent progress towards scaling up multimodal vision-language models, these models are still known to struggle on compositional generalization benchmarks such as Winoground. We find that a critical component lacking from current vision-language models is relation-level alignment: the ability to match directional semantic relations in text (e.g., "mug in grass") with spatial relationships in the image (e.g., the position of the mug relative to the grass). To tackle this problem, we show that relation alignment can be enforced by encouraging the directed language attention from 'mug' to 'grass' (capturing the semantic relation 'in') to match the directed visual attention from the mug to the grass. Tokens and their corresponding objects are softly identified using the cross-modal attention. We prove that this notion of soft relation alignment is equivalent to enforcing congruence between vision and language attention matrices under a 'change of basis' provided by the cross-modal attention matrix. Intuitively, our approach projects visual attention into the language attention space to calculate its divergence from the actual language attention, and vice versa. We apply our Cross-modal Attention Congruence Regularization (CACR) loss to UNITER and improve on the state-of-the-art approach to Winoground.

The number of international benchmarking competitions is steadily increasing in various fields of machine learning (ML) research and practice. So far, however, little is known about the common practice as well as bottlenecks faced by the community in tackling the research questions posed. To shed light on the status quo of algorithm development in the specific field of biomedical imaging analysis, we designed an international survey that was issued to all participants of challenges conducted in conjunction with the IEEE ISBI 2021 and MICCAI 2021 conferences (80 competitions in total). The survey covered participants' expertise and working environments, their chosen strategies, as well as algorithm characteristics. A median of 72% challenge participants took part in the survey. According to our results, knowledge exchange was the primary incentive (70%) for participation, while the reception of prize money played only a minor role (16%). While a median of 80 working hours was spent on method development, a large portion of participants stated that they did not have enough time for method development (32%). 25% perceived the infrastructure to be a bottleneck. Overall, 94% of all solutions were deep learning-based. Of these, 84% were based on standard architectures. 43% of the respondents reported that the data samples (e.g., images) were too large to be processed at once. This was most commonly addressed by patch-based training (69%), downsampling (37%), and solving 3D analysis tasks as a series of 2D tasks. K-fold cross-validation on the training set was performed by only 37% of the participants and only 50% of the participants performed ensembling based on multiple identical models (61%) or heterogeneous models (39%). 48% of the respondents applied postprocessing steps.

Human modeling and relighting are two fundamental problems in computer vision and graphics, where high-quality datasets can largely facilitate related research. However, most existing human datasets only provide multi-view human images captured under the same illumination. Although valuable for modeling tasks, they are not readily used in relighting problems. To promote research in both fields, in this paper, we present UltraStage, a new 3D human dataset that contains more than 2K high-quality human assets captured under both multi-view and multi-illumination settings. Specifically, for each example, we provide 32 surrounding views illuminated with one white light and two gradient illuminations. In addition to regular multi-view images, gradient illuminations help recover detailed surface normal and spatially-varying material maps, enabling various relighting applications. Inspired by recent advances in neural representation, we further interpret each example into a neural human asset which allows novel view synthesis under arbitrary lighting conditions. We show our neural human assets can achieve extremely high capture performance and are capable of representing fine details such as facial wrinkles and cloth folds. We also validate UltraStage in single image relighting tasks, training neural networks with virtual relighted data from neural assets and demonstrating realistic rendering improvements over prior arts. UltraStage will be publicly available to the community to stimulate significant future developments in various human modeling and rendering tasks.

In this paper, we present a pure-Python open-source library, called PyPop7, for black-box optimization (BBO). It provides a unified and modular interface for more than 60 versions and variants of different black-box optimization algorithms, particularly population-based optimizers, which can be classified into 12 popular families: Evolution Strategies (ES), Natural Evolution Strategies (NES), Estimation of Distribution Algorithms (EDA), Cross-Entropy Method (CEM), Differential Evolution (DE), Particle Swarm Optimizer (PSO), Cooperative Coevolution (CC), Simulated Annealing (SA), Genetic Algorithms (GA), Evolutionary Programming (EP), Pattern Search (PS), and Random Search (RS). It also provides many examples, interesting tutorials, and full-fledged API documentations. Through this new library, we expect to provide a well-designed platform for benchmarking of optimizers and promote their real-world applications, especially for large-scale BBO. Its source code and documentations are available at https://github.com/Evolutionary-Intelligence/pypop and https://pypop.readthedocs.io/en/latest, respectively.